(3S)-3-(4-chlorophenyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
Fmoc-S-3-Amino-3-(4-chloro-phenyl)-propionic acid
CAS: 479064-91-0
Molecular Formula: C24H20ClNO4
(3S)-3-(4-chlorophenyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid - Names and Identifiers
(3S)-3-(4-chlorophenyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid - Physico-chemical Properties
| Molecular Formula | C24H20ClNO4 |
| Molar Mass | 421.87 |
| Density | 1.336±0.06 g/cm3(Predicted) |
| Boling Point | 642.2±55.0 °C(Predicted) |
| pKa | 4.22±0.10(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD03427998 |
(3S)-3-(4-chlorophenyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid - Introduction
Fmoc-S-3-Amino-3-(4-chloro-phenyl)-propionic acid is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: a solid powder
-Chemical formula: C21H18ClNO4S
-Molecular weight: 415.88g/mol
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide (DMSO) and acetonitrile, insoluble in water.
Use:
Fmoc-S-3-Amino-3-(4-chloro-phenyl)-propionic acid is a commonly used organic synthesis intermediate, which is often used to protect amino acid groups and synthesize peptide chains in solid phase synthesis (peptide synthesis).
Preparation Method:
The preparation of Fmoc-S-3-Amino-3-(4-chloro-phenyl)-propionic acid typically involves several steps:
Synthesis of 1. 3-amino -3-(4-chlorophenyl) propionic acid: 3-amino -3-(4-chlorophenyl) propionic acid was obtained by reacting 3-amino -3-(4-chlorophenyl) propionic acid with 4-chlorophenylacetic acid.
2. Through the oxidation of aromatic hydroxyl and the steps of organic synthesis, the Fmoc protecting group was introduced into 3-amino -3-(4-chlorophenyl) propionic acid.
Safety Information:
- Fmoc-S-3-Amino-3-(4-chloro-phenyl)-propionic acid needs to be operated in a laboratory and comply with relevant chemical safety procedures.
-It may irritate the skin, eyes and respiratory system and should be avoided. When in use, it is recommended to wear personal protective equipment, such as laboratory gloves, safety glasses and protective masks.
-When handling this compound, pay attention to avoid inhalation or intake, and pay attention to the storage and disposal of waste to ensure environmental safety. In the event of an accident, seek medical help immediately.
Nature:
-Appearance: a solid powder
-Chemical formula: C21H18ClNO4S
-Molecular weight: 415.88g/mol
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide (DMSO) and acetonitrile, insoluble in water.
Use:
Fmoc-S-3-Amino-3-(4-chloro-phenyl)-propionic acid is a commonly used organic synthesis intermediate, which is often used to protect amino acid groups and synthesize peptide chains in solid phase synthesis (peptide synthesis).
Preparation Method:
The preparation of Fmoc-S-3-Amino-3-(4-chloro-phenyl)-propionic acid typically involves several steps:
Synthesis of 1. 3-amino -3-(4-chlorophenyl) propionic acid: 3-amino -3-(4-chlorophenyl) propionic acid was obtained by reacting 3-amino -3-(4-chlorophenyl) propionic acid with 4-chlorophenylacetic acid.
2. Through the oxidation of aromatic hydroxyl and the steps of organic synthesis, the Fmoc protecting group was introduced into 3-amino -3-(4-chlorophenyl) propionic acid.
Safety Information:
- Fmoc-S-3-Amino-3-(4-chloro-phenyl)-propionic acid needs to be operated in a laboratory and comply with relevant chemical safety procedures.
-It may irritate the skin, eyes and respiratory system and should be avoided. When in use, it is recommended to wear personal protective equipment, such as laboratory gloves, safety glasses and protective masks.
-When handling this compound, pay attention to avoid inhalation or intake, and pay attention to the storage and disposal of waste to ensure environmental safety. In the event of an accident, seek medical help immediately.
Last Update：2024-04-10 22:29:15
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